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A deadly herpes virus is threatening oysters around the world



Oysters, a delicacy eaten on most coastlines of the world, are a multi-billion-dollar industry. They also are intriguing to study from a health perspective. Oysters feed by filtering tiny plankton from the surrounding water, processing up to 50 gallons per oyster daily. In doing so, they improve water quality and make their ecosystems healthier. But the water that they grow can be filled with disease-causing microorganisms that can affect both oysters and humans.

Today a deadly herpes virus, Ostreid herpesvirus 1 (OsHV-1), is threatening Pacific oysters (Crassostrea gigas), the world’s most popular and valuable oyster species. It is almost certain to spread more widely in our globally connected world.

I know what you’re thinking: “Oysters get herpes??” Yes, and they can also can get sick from other types of pathogens and stresses. But you won’t contract this virus from eating an oyster, whether you enjoy them on the half-shell or cooked. OsHV-1 can infect other bivalve species, like some animal herpes viruses that can cross species barriers, but it is genetically distinct from other animal herpes viruses and does not infect humans.

With support from the NOAA Sea Grant aquaculture program, I’m working with a diverse team that includes researchers, regulators and outreach specialists in the United States and abroad to better prepare the U.S. oyster industry for the spread of this virus.


Dead Pacific oyster sampled during a OsHV-1 mortality event this summer in Tomales Bay, California.
Colleen Burge, CC BY-ND
Deadly and spreading
Pacific oysters are native to Asia and are the most popular and valued oyster for aquaculture globally. Humans transferred them from their native range to multiple grow-out areas globally, including France, the United States and Australia. They are the primary species grown on the U.S. West Coast, whereas both wild and cultured Eastern oysters grow on the East and Gulf coasts. In contrast to Eastern oysters, Pacific oysters were relatively resistant to infectious diseases until OsHV-1 emerged in the early 1990s.

Herpes is often fatal to Pacific oysters. That’s especially true for OsHV-1 microvariants – mutant variants of OsHV-1 which are more virulent than the original reference strain. These viruses are spreading globally, causing mass mortalities of Pacific oysters.

An OsHV-1 microvariant was first detected in France in 2008, where it killed 80 to 100 percent of affected oyster beds. Since then, similar variants have caused mass mortalities of oysters in many European countries. A 2010 outbreak in England killed over eight million oysters.

OsHV-1 microvariants also infect Pacific oysters in New Zealand and Australia. Their spread in Australia, in particular to Tasmania, has crippled the Australian Pacific oyster aquaculture industry.

Resistance is the best defense
U.S. oyster growers are strongly concerned about the spread of OsHV-1 microvariants globally. I was part of the team that first detected OsHV-1 in Tomales Bay, California. To date the virus has been detected only in oysters in Tomales Bay and an adjacent bay, and no microvariants have been found yet in U.S. waters. The California OsHV-1 causes mortalities of young Pacific oysters, but is thought to be less virulent than OsHV-1 microvariants.

Given the spread of the OsHV-1 microvariants elsewhere around the world, it may only be a matter of time until they reach U.S. coastal bays or other nonimpacted oyster growing areas. We spent the summer of 2017 conducting experiments in Tomales Bay to determine whether any cultured U.S. oysters species are resistant to OsHV-1, and soon will also conduct laboratory challenges with OsHV-1 microvariants.

Once OsHV-1 is established within a bay, mass oyster deaths typically occur each year during the summer when water temperatures are warm. The situation is analogous to a human who is infected with herpes and periodically get cold sores. Normally the virus is latent (present at a low level) and does not cause cold sores. But after a stressful situation, the virus replicates and cold sores emerge.

Not all oysters die of herpes, and if OsHV-1 behaves like other herpes viruses, it probably remains present latently within infected oysters’ tissues and is reactivated after a stressful event. For oysters, most of the evidence for virus reactivation points to warm summer water conditions.

A deadly herpes virus is threatening oysters around the world

 

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